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Immunization against hepatitis B virus is particularly significant for preventing hepatitis D virus because hepatitis D is a unique virus that only occurs in individuals who are infected with hepatitis B. The two viruses share a close relationship; hepatitis D can only replicate in the presence of hepatitis B virus. Therefore, by vaccinating against hepatitis B, an individual is also protected from hepatitis D, making the vaccination a crucial intervention in preventing co-infection.

While hepatitis A and hepatitis C are important viruses in terms of liver health, they do not have this dependency on hepatitis B. Hepatitis A has its own vaccine, and hepatitis C has no vaccine available, meaning that vaccination against hepatitis B does not provide additional protection against these viruses. Similarly, HIV is unrelated to hepatitis B and does not have a direct preventive relationship with the hepatitis B vaccine.