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A patient with mononucleosis should not play sports until the symptoms subside due to which of the following concerns?

  1. Enlarged spleen

  2. Stress on the liver

  3. Possible kidney complications

  4. Malaise and fatigue

The correct answer is: Enlarged spleen

The concern that a patient with mononucleosis should not play sports until symptoms subside primarily relates to the risk of an enlarged spleen. Mononucleosis, often caused by the Epstein-Barr virus, can lead to significant enlargement of the spleen, a condition known as splenomegaly. Engaging in physical activity or contact sports while the spleen is enlarged can pose a serious risk, as the spleen is more susceptible to rupture, which is a medical emergency and can lead to severe internal bleeding. While other factors such as stress on the liver, possible kidney complications, and malaise and fatigue are important considerations in the context of mononucleosis, they do not present the same immediate and severe risk associated with an enlarged spleen during physical activity. Therefore, the primary concern in delaying sports participation is to prevent potential complications related to an enlarged spleen.